Assessment of the Change in Hematological parameters in patients with chronic renal failure on maintenance hemodialysis

Abstract

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In chronic kidney disease (CKD), there is a progressive, irreversible deterioration in renal function that may end with renal failure, which can be substituted by maintenance hemodialysis (MHD), this can lead to side effects on the blood components. Anemia is a common manifestation in chronic renal failure (CRF) patients on MHD and is associated with a decline in the quality of patients' life, hematological parameters are usually, affected in those patients. The study aimed to assess the changes in the hematological parameters of CRF patients in comparison with the healthy group. This study was conducted at the Misurata dialysis center, blood samples were collected from 40 (20 males and 20 females) CRF patients undergoing hemodialysis before dialysis sessions and 20 samples from healthy subjects as a control group. The blood parameters were detected by the auto analyzer MINDRAY BC-2800 system. The current study showed that the dialysis had an apparent effect on the hematological parameters, there was a decrease in most of the parameters investigated in the patients compared to the controls (p<0.05), RBCs count, Hb, and Hct of patients were lower than the normal, Plts, MCH, AND MCHC were lower in the patients but within the normal ranges, significant differences than the controls were reported (p<0.05), The MCV was higher but within the normal range in the patients than the controls with significant differences (p<0.05). Moreover, the Total WBCs count was nearly equal in both groups without any differences (p>0.05). We concluded that the dialysis process has a clear effect on the hematological parameters, and recommends the screening of hematological parameters before performing hemodialysis.